VON WILLEBRAND DISEASE

Description

  • Bleeding disorder
  • Caused by deficiency of von Willebrand factor which helps blood to clot
  • The condition is most often inherited

Symptoms

  • Abnormal menstrual bleeding
  • Bleeding of the gums
  • Easy Bruising
  • Excessive Nosebleeds
  • Skin rash
  • Blood in the stool or urine
  • Bruises with lumps that form underneath the skin

Causes

  • Genetic mutation
  • Having low levels of factor VIII
  • Autoimmune diseases
  • Scarcity of von Willebrand factor
  • Hypothyroidism
  • Certain medications

Risk Factors

  • Family history
  • Even one affected parent

Diagnostic Tests

  • Medical history
  • Physical examination
  • Blood typing
  • Special blood tests to check for:
  • Von Willebrand factor (vWF) antigen
  • Ristocetin cofactor activity
  • Factor VIII clotting activity
  • Von Willebrand factor multimers
  • Platelet function test (PFA-100)

Treatment

  • Desmopressin (DDAVP) medications
  • Replacement therapies
  • Contraceptives
  • Anti-fibrinolytic or clot-stabilizing medications
  • Fibrin sealants

Medications

  • Aminocaproic acid (Amicar)
  • Tranexamic acid (Cyklokapron; Lysteda)
  • Alphanate

Prevention

  • Genetic counseling in case of family history

Lifestyle Management

  • Switch pain relievers
  • Inform the doctor and dentist about the condition
  • Mainatin a healthy weight
  • Be active
  • Avoid injury-causing activities
  • Avoid blood-thinning medications such as Aspirin, Ibuprofen