PAGET’S DISEASE OF BONE

Description

  • disrupts the normal cycle of bone renewal and repair
  • bones weakened

Symptoms

  1. Pain in your bones and joints
  2. Tingling and weakness
  3. Bone deformities
  4. Paget’s disease of bone in the pelvis can cause hip pain.
  5. overgrowth of bone in the skull can cause hearing loss or headaches
  6. If your spine is affected, nerve roots can become compressed.
  7. As the bones weaken, they may bend
  8. joint tenderness or stiffness – usually worse when you wake up, but improves once you start to move
  9. joints appearing larger than normal
  10. difficulty moving your affected joints

Causes

  1. canine distemper virus – responsible for a type of viral infection that affects animals, mainly dogs (distemper)
  2. respiratory syncytial virus (RSV) – which causes respiratory infections during childhood
  3. measles virus
  4. genetic and environmental factors

Diagnostic Tests

  • X rays
  • bone scan
  • biopsy
  • CT,MRI scans
  • Alkaline phosphatase (ALP)

Treatments

  • physical therapy
  • surgery
  • pain killers
  • Bisphosphonates
  • dietary supplements
  • Osteoporosis drugs
  • Medications

    • Alendronate (Fosamax)
    • Ibandronate (Boniva)
    • Pamidronate (Aredia)
    • Risedronate (Actonel)
    • Zoledronic acid (Zometa, Reclast)
    • calcitone

    Lifestyle Management

    • prevent falls
    • eat well
    • exercise regularly