YOUNG’S SYNDROME

Description:

  • Rare syndrome comprises of three components:
  • Obstructive azoospermia
  • Bronchiectasis
  • Sinus disease

Symptoms:

  • Decreased fertility
  • Recurrent respiratory infections
  • Abnormality of the pancreas
  • Shortness of breath
  • Infertility
  • Sinusitis
  • Bronchiectasis
  • Fever
  • Sinus pain
  • Chills
  • Recurring bronchitis
  • Recurring sinus infections
  • Excessive maternal milk production
  • Rapid maternal weight gain
  • Fetal death
  • Large fetus
  • Lung infections
  • Clubbing of fingers and toes

Causes:

  • Might be genetic-found in identical twins
  • Childhood exposure to mercury
  • Speculated to be due to defects in ciliary motility

Risk factors:

  • Exposure to mercury
  • Complications might lead to severe bronchiectasis and pulmonary problems
  • Normal functioning of the lung to be affected

Diagnostic tests:

  • Based on the presence of signs and symptoms
  • Physical examination
  • Lab tests
  • Pulmonary function test
  • Semen sample analysis: check for the sperm motility and structural abnormalities
  • X-ray & CT scans- check for lung infection and sinus malformations

Treatments:

  • Treatment-focused on symptoms
  • Control of infections with antibiotics and bronchodilators
  • Hormonal supplementation for treatment of azoospermia
  • Microsurgical techniques

Lifestyle Management:

  • Emotional support to cope up with the emotional ups and downs
  • Medical treatment to alleviate the symptoms