THROMBOCYTOSIS

Description

Thrombocytosis is a disorder in which your body produces too many platelets (thrombocytes), which play an important role in blood clotting

Symptoms

  • Headache
  • Dizziness or lightheadedness
  • Chest pain
  • Weakness
  • Fainting
  • Temporary vision changes
  • Numbness or tingling of the hands and feet

Causes

  • Essential thrombocythemia: bone marrow disorder
  • Reactive thrombocytosis causes include:
  • Acute bleeding and blood loss
  • Allergic reactions
  • Cancer
  • Chronic kidney failure or another kidney disorder
  • Exercise
  • Heart attack
  • Coronary artery bypass
  • Infections, including tuberculosis
  • Iron deficiency
  • Vitamin deficiency
  • Removal of your spleen
  • Hemolytic anemia
  • Inflammation, such as from rheumatoid arthritis, celiac disease, connective tissue disorders or inflammatory bowel disease
  • Major surgery
  • Pancreatitis
  • Trauma
  • Burns
  • Medications that can cause reactive thrombocytosis include:
  • Epinephrine (AUVI-Q, EpiPen, others)
  • Tretinoin (Retin-A, Renova, others)
  • Vincristine Sulfate (Marqibo Kit)
  • Heparin sodium

Risk Factors

  • Age 60 years or older
  • History of thrombosis
  • Platelet count greater than 1500 x 10 9/L (1.5 million/µL)
  • Obesity
  • Cardiovascular risk factors such as smoking, hypertension, and hypercholesterolemia
  • Markers of hypercoagulability such as factor V Leiden and antiphospholipid antibodies
  • JAK2 mutation

Diagnostic Tests

  • Physical examination
  • A routine blood test
  • A blood smear
  • Bone marrow aspiration and biopsy
  • Genetic testing
  • Test for markers of inflammation

Treatment

  • Plateletpheresis
  • Medications:
  • Hydroxyurea
  • Anagrelide

Lifestyle Management

  • Eat healthy foods
  • Increase your physical activity
  • Achieve or maintain normal weight
  • Stop smoking
  • Stress management