SOFT TISSUE SARCOMA

Description

Group of rare cancers affecting the tissues that connect, support and surround other body structures and organs.

  1. different types of soft tissue sarcoma
  2. leiomyosarcomas – which develop in muscle tissue
  3. liposarcomas  – which develop in fat tissue
  4. angiosarcomas  – which develop in the cells of the blood or lymph vessels
  5. gastrointestinal stromal tumours (GISTs)  – which can develop in the connective tissues that support the organs of the digestive system

Symptoms

  1. A noticeable lump or swelling
  2. Pain, if a tumor presses on nerves or muscles
  3. intestinal blockage. 

Causes

  1. Kaposi’s sarcoma caused by human herpes virus 8 (HHV-8)
  2. age genetic conditions
  3. certain chemicals
  4. previous radiotherapy

Risk Factors

  • Basal cell nevus syndrome increases your risk of basal cell skin cancer, rhabdomyosarcoma, and fibrosarcoma.
  • Inherited retinoblastoma causes a kind of childhood eye cancer, but it can also increase the risk of other soft tissue sarcomas.
  • Li-Fraumeni syndrome increases the risk of many kinds of cancer, often from radiation exposure.
  • Gardner’s syndrome leads to cancers in the stomach or bowel.
  • Neurofibromatosis can cause nerve sheath tumors.
  • Tuberous sclerosis can result in rhabdomyosarcoma.
  • Werner’s syndrome can cause many health problems, including an increased risk of all soft tissue sarcomas.
  • toxin &radiation exposure

Diagnostic Tests

  • biopsy
  • X-rays,CT scan
  • immunohistochemistry, which looks for antigens or sites on tumor cells to which certain antibodies can attach
  • cytogenic analysis, which looks for changes in the chromosomes of the tumor cells
  • fluorescence in situ hybridization (FISH), a test to look for certain genes or short pieces of DNA
  • flow cytometry, which is a test that looks at the number of cells, their health, and the presence of tumor markers on the surface of cells

Treatments

  • surgery
  • chemotherapy
  • radiation therapy
  • Targeted drugs block specific abnormal signals

Medications

  • Imatinib (Gleevec)
  • Sunitinib (Sutent)
  • Regorafenib (Stigvara)
  • Pazopanib (Votrient)

Lifestyle Management

  •  Keeping your close relationships strong
  • Learn enough about sarcoma to make decisions about your care.
  • physiotherapy
  • occupational therapyy