1. rare but serious condition that causes swelling in the liver and brain.
  2. most often affects children and teenagers recovering from a viral infection, most commonly the flu or chickenpox.


  1. vomiting that lasts for several hours
  2. lethargy or drowsiness
  3. diarrhea, especially in infants
  4. rapid breathing
  5. aggressive behavior or irritability
  6. confusion or any other unusual changes in mental status
  7. seizures
  8. hearing loss
  9. double vision
  10. paralysis or loss of muscle function
  11. abnormal speech


  1.  triggered by using aspirin to treat a viral illness or infection 
  2. Fatty acid oxidation disorders
  3. exposure to toxins- insecticides, herbicides and paint thinner

Risk Factors

  • Using aspirin to treat a viral infection, such as flu, chickenpox or an upper respiratory infection
  • Having an underlying fatty acid oxidation disorder
  • Children and adolescents

Diagnostic Tests

  • blood,urine tests
  • skin,liver biopsy
  • spinal tap
  • MRI,CT scan


  • providing electrolytes, hydration, and glucose intravenously
  • providing steroids and diuretics to reduce brain swelling and excess fluid
  • providing anti-seizure medication as needed
  • maintaining oxygen levels with breathing support (ventilator) if necessary
  • intravenous fluids
  • ammonia detoxicants – medications to reduce the level of ammonia
  • anticonvulsants – medications to control seizures


avoid aspirin medications like

  • oil of wintergreen
  • acetylsalicylic acid
  • acetylsalicylate
  • salicylic acid
  • salicylate
  • paracetamol,ibuprofen
  • Bonjela and Bonjela Cool Mint Gel